Connect with us

Medical

Breast Cancer: Affordable Tests Could Result in Relapse Risk Z

Published

on

Researchers are working on an affordable test that determines the response of a breast cancer patient to hormone therapy to quickly predict the likelihood of a relapse.

Scientists estimate the cost of the test at about 60 pounds per patient, compared to currently available genomic tests which cost over 20 times that.

It finds deviations in cancer cell growth rate after treatment with aromatase inhibitors which inhibit estrogen production.

Researchers observe that using tests could reassure women who could do well under standard treatment and identify the ones are more likely to relapse.

”This important trial is the largest of its kind in the world and involved around 4,500 patients in 130 NHS breast units throughout the UK,’’ said the trial chief investigator, Professor Ian Smith, an honorary cancer medicine professor at the Cancer Research Institute in London.

‘’We have shown that giving patients with early breast cancer two weeks of simple endocrine therapy using aromatase inhibitor tablets before surgery allows us to determine what is the most appropriate medical treatment after surgery for each patient.

”In particular, it helps us identify which patients could avoid chemotherapy with all its unpleasant toxicities. The test is much cheaper and easier than current genomic tests, and we believe it should become part of the standard treatment for early breast cancer.”

A study of women with hormone-positive early-stage breast cancer by researchers team from Cancer Research Institute, London, and the Royal Marsden NHS Foundation Trust, in a situation where cancer cells grow, responding to progesterone or estrogen hormone, or both.

Of 4,480 patients, two-thirds received aromatase inhibitors, either anastrozole or letrozole, two weeks prior to and after surgery. The rest were treated with surgery, receiving aromatase inhibitors at the usual time, after surgery only.

All patients were instructed to proceed with hormone treatment up to at least 5 years as part of standard care to reduce the coming back risk of breast cancer.

The researchers used a cancer growth rate test. It looks for Ki67 protein in tumor samples to check for any effect of the pre-surgery hormone treatment. The team could find out from the test the patients who were at higher or lower risk to see a return of the disease.

‘’Sadly, breast cancer can return for some women, so a new way to help predict if their cancer will return means doctors could monitor these patients more closely – catching any sign of cancer as early as possible is crucial for improving survival,’’ said Professor Arnie Purushotham. A senior clinical advisor UK Cancer Research.

‘’This research could also have implications for how doctors decide to treat early-stage, hormone-positive breast cancer – potentially triaging women depending on the risk of their cancer coming back.’’

Continue Reading
Click to comment
Subscribe
Notify of
0 Comments
Inline Feedbacks
View all comments

Health & Fitness

The Dawn of AI-Enhanced Rehabilitation: How AI-Powered Trousers are Revolutionizing Stroke Recovery

Published

on

By

In the quaint town of Penarth, Vale of Glamorgan, a remarkable story of resilience and technological innovation is unfolding. Julie Lloyd, a 65-year-old stroke survivor, is relearning to walk, aided by a groundbreaking piece of technology: trousers powered by artificial intelligence (AI). This pioneering trial in the UK marks a significant leap in medical technology, offering new hope to stroke victims worldwide.

The Breakthrough in Stroke Rehabilitation

Julie’s journey is not just a personal triumph but a beacon of hope for millions affected by strokes. According to the World Health Organization, strokes are the second leading cause of death globally, and the leading cause of acquired disability among adults. The road to recovery is often long and arduous, with traditional rehabilitation methods providing varying degrees of success.

The AI-powered trousers represent a paradigm shift in rehabilitation technology. As Julie puts it, “I really feel this is the breakthrough for stroke victims that has been much and long awaited for.” This sentiment echoes the sentiments of many in the medical community who have long sought more effective ways to aid stroke recovery.

How the Technology Works

The AI trousers are a marvel of modern engineering and medical science. They function by using a series of sensors and motors that work in tandem with the wearer’s movements. This technology is not just about physical support; it’s about enhancing the body’s natural ability to relearn movements. The AI component analyses the wearer’s gait, providing real-time adjustments to improve walking patterns, much like a physical therapist would.

This approach is grounded in the concept of neuroplasticity, the brain’s ability to reorganize itself by forming new neural connections. By assisting in the correct movement patterns, the trousers help the brain to ‘relearn’ walking, potentially speeding up the recovery process.

The Impact on Stroke Rehabilitation

The implications of this technology are vast. For stroke survivors, the journey to recovery can be filled with frustration and despair. Traditional rehabilitation methods can be slow and, at times, ineffective. The AI trousers offer a more dynamic and responsive form of therapy that could revolutionize how we approach stroke rehabilitation.

In a study conducted by the American Stroke Association, it was found that early and individualized rehabilitation can significantly improve outcomes for stroke survivors. The AI trousers align perfectly with this philosophy, offering a tailored rehabilitation experience that adapts to the individual’s needs.

Challenges and Future Prospects

Despite the promise, the road ahead for AI in medical rehabilitation is not without challenges. Cost and accessibility are significant concerns. Cutting-edge technology often comes with a high price tag, potentially putting it out of reach for many who could benefit from it.

Moreover, there’s the challenge of integrating such technology into existing healthcare systems. As noted by experts in healthcare technology, the adoption of new medical technologies often faces hurdles in terms of regulatory approval, practitioner training, and patient acceptance.

However, the future looks bright. As AI and robotics continue to advance, we can expect these technologies to become more affordable and widespread. The potential for AI to aid in various aspects of healthcare, from diagnosis to treatment and rehabilitation, is enormous.

Conclusion

Julie Lloyd’s story is just the beginning. As we stand on the cusp of a new era in medical technology, the possibilities are endless. The AI-powered trousers are more than just a piece of technology; they are a symbol of hope and a testament to human ingenuity. For stroke survivors around the world, this could be the dawn of a new day in rehabilitation, one where technology and human resilience come together to create new possibilities.

Continue Reading

Medical

AI-Powered Medical Database Aims to Revolutionize Doctor-Patient Interactions

Published

on

By

Artificial Intelligence (AI) is making inroads into various sectors, and healthcare is no exception. According to a recent NPR article, Dr. Michael Mansour of Massachusetts General Hospital is among the early adopters testing an AI-enhanced version of UpToDate, a widely-used medical database. This experimental version employs generative AI to provide doctors with more targeted information, aiming to streamline the diagnostic process.

Wolters Kluwer Health, the company behind UpToDate, is working on making the database more conversational, allowing doctors to maintain the context of their queries. While the technology is still in beta and has some kinks to work out, the potential is enormous. AI could not only assist in making accurate diagnoses but also free up doctors’ time, allowing them to focus more on patient care. As Dr. Marc Succi of Mass General Brigham aptly puts it, “AI won’t replace doctors, but doctors who use AI will replace doctors who do not.”

Continue Reading

Medical

A New way around Drug Resistant Tuberculosis

Published

on

By

Researchers at Purdue University have created a powerful compound that specifically tackles Tuberculosis, a leading killer worldwide.

The scientists came up with a series of inhibitors that destroy TB by targeting a protein necessary for the survival of the TB molecule.

Tuberculosis destabilizes the immunity of patients with the help of Protein Tyrosine Phosphates B (mPTPB). Their findings were published in the Journal of Medicinal Chemistry.

“The death toll from TB is particularly high because of drug-resistant strains,” said Zhong-Yin Zhang, distinguished professor and head of Purdue’s Department of Medicinal Chemistry and Molecular Pharmacology and director of Purdue Institute for Drug Discovery. “These inhibitors are part of a promising new approach to developing TB therapeutic agents with novel targets and mechanisms of action to help save more lives.”

Right now, doctors rely on antibiotic preparations to treat Tuberculosis. The problem is that many patients don’t complete their dose of antibiotics and this non-adherence leads to the development of drug resistant tuberculosis.

“We developed a platform to target mPTPB for novel anti-TB agents that builds on technologies we pioneered to modulate abnormal protein tyrosine phosphatase activity for the treatment of diseases such as cancer, diabetes and autoimmune disorders,” Zhang elaborated.

According to Zhang, the inhibitors’ have unique properties that make them incredibly useful. They have a lighter molecular weight and superior metabolic stability. They give scientists an excellent opportunity to create better treatments for Tuberculosis.

The visionary scientists are already working to patent the exciting new technology. The hunt is on for partners who will work with Purdue to further the development of the new technology. This is together with the Purdue Research Foundation Office of Technology Commercialization.

Continue Reading

Trending